Indian origin scientist V Ramakrishnan wins 2009 Chemistry Nobel

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Tamil Nadu-born Venkatraman Ramakrishnan, a senior scientist at the MRC Laborartory of Molecular Biology at Cambridge, has been awarded the Nobel Prize in Chemistry for 2009 along with two others, the Nobel Committee announced on Wednesday. Born in 1952 in Chidambaram, Ramakrishnan shares the Nobel prize with Thomas E Steitz (US) and Ada E Yonath (Israel) for their "studies of the structure and function of the ribosome".

Ramakrishnan earned his B.Sc. in Physics (1971) from Baroda University and his Ph.D. in Physics (1976) from Ohio University. He moved into biology at the University of California, San Diego, where he took a year of classes, then conducted research with Dr Mauricio Montal, a membrane biochemist.

"This year's Nobel Prize in Chemistry awards Venkatraman Ramakrishnan, Thomas A Steitz and Ada E Yonath for having showed what the ribosome looks like and how it functions at the atomic level," the Nobel committee said in its citation. All three have used a method called X-ray crystallography to map the position for each and every one of the hundreds of thousands of atoms that make up the ribosome, it said.

"This year's three Laureates have all generated 3D models that show how different antibiotics bind to the ribosome. These models are now used by scientists to develop new antibiotics, directly assisting the saving of lives and decreasing humanity's suffering," the citation said.

Better known as Venky among friends, Ramakrishnan started out as a theoretical physicist. After graduate school, he designed his own 2-year transition from physics to biology.

As a postdoctoral fellow at Yale University, he worked on a neutron-scattering map of the small ribosomal subunit of E Coli. He has been studying ribosome structure ever since. Ramakrishnan has authored several important papers in academic journals.

In the August 26, 2000 issue of Nature, Ramakrishnan and his coworkers published the structure of the small ribosomal subunit of Thermus thermophilus, a heat-stable bacterium related to one found in the Yellowstone hot springs. With this 5.5 Angstrom-resolution structure, Ramakrishnan's group identified key portions of the RNA and, using previously determined structures, positioned seven of the subunit's proteins.

In the September 21, 2000 issue of Nature, Ramakrishnan published two papers. In the first of these, he presents the 3 Angstrom structure of the 30S ribosomal subunit.

His second paper reveals the structures of the 30S subunit in complex with three antibiotics that target different regions of the subunit. In this paper, Ramakrishnan discusses the structural basis for the action of each of these drugs.

After his postdoctoral fellowship, Ramakrishnan joined the staff of Brookhaven National Laboratory in the US. There, he began his collaboration with Stephen White to clone the genes for several ribosomal proteins and determine their three-dimensional structures.

He was also awarded a Guggenheim fellowship during his tenure there, and he used it to make the transition to X-ray crystallography. Ramakrishnan moved to the University of Utah in 1995 to become a professor in the Department of Biochemistry. There, he initiated his studies on protein-RNA complexes and the entire 30S subunit.

He since moved to the MRC Laboratory of Molecular Biology in Cambridge, where he is a Senior Scientist and Group Leader in the Structural Studies Division. He joins the list of several Nobel laureates who worked at the laboratory




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Wake Up Sid Movie Review

A scene from Wake Up SidComing of age is never an instant experience. It takes time, a sweet amount at that, before realisation hits. As if on cue, Wake Up Sid [ Images ] follows the tempo of its eponymous hero.

There's not much of a story to tell. It could be related in a five-minute music video -- about a boy who takes everything; family, education, comforts for granted and a slightly older, independent girl. What happens when the twain share the same roof?

And so the first quarter of writer/director Ayan Mukerji's fresh, romantic and feel-good caper about a boy-in-limbo's metamorphosis into a man-in-charge is leisurely paced, as if unapologetically echoing Sid's laidback temperament, an affable yet clueless college lad who snaps at his folks, doodles on his accounts text book to party hard at Ruby Tuesday, gaming arcades, shopping malls and discotheques with his two best friends – a plump Betty-types (an instantly likeable Shikha Talsania) and a bearded sensitive Joe (Namit Das, half-amusing), driving a sleek Honda CRV, with an exceptionally trendy wardrobe of cartoon-themed tees (Joker, Dastardly, Beavis & Butthead, Ghostbusters, Tom & Jerry, Snoopy to name a few), cute 'n' colourful boxers and a room-filled with all sorts of fanboy toys, gadgets and gizmos.

Phew, right? All these cool props to emphasise on Sid's affluent, metropolitan, spoilt character are in excess, in fact to the point of distraction. Even so, most of the aforesaid is swiftly established in a lilting Shankar-Ehsaan-Loy number, Kya karoon.

Immediately after, the momentum tires down into scenes with either one too many ungainly pauses or dialogues (by Niranjan Iyengar) that tend to ramble on. Like Sid's tribute to Mumbai [ Images ] is characteristically a Mumbaikar showing off the awesomeness of his city to a visitor to the extent the other feels sorry he/she hails from anywhere else. But the verbosity with which he is asked to convey Mumbai's magical magnetism, monsoon madness and insomniac charm does not appeal. What does is him quoting Dil Chahta Hai [ Images ]'s legendary punch-line, 'Be a man'.

Ranbir KapoorWhile it would be daft to dub Wake Up Sid a Dil Chahta Hai clone, it clearly pays tribute to Farhan Akhtar's [ Images ] 2001 breakthrough directorial debut. Ayan's Sid appears to be an amalgamation of all of the three leading men in DCH. His directionless-and-loving-it smugness is derived from Aamir Khan's [ Images ] Aakash. He sports a hip 'n' boyish wardrobe/haircut reminiscent of Saif Ali Khan's [ Images ] Sameer whilst sharing the creative sensibilities of namesake Siddharth aka Sid played by Akshaye Khanna [ Images ].

An urban Peter Pan, Sid celebrates pop culture, frivolity, joblessness and Mumbai, his interpretation of Neverland, with such disarming indifference, it's impossible, even if impractical, not to like the guy. And because Ranbir Kapoor [ Images ] plays him so unbelievably well, you end up falling in love with him.

Frequently in the movie, Ranbir rises well above the scene making the latter look utterly mediocre in its capacity. Such is his impact. There are scenes which portray him indulging in supreme cheesiness like dishing out last-minute bread 'n' jam cakes with a matchstick doing a candle's job or slipping into his ladylove's kurta as an expression of intimacy. Any other actor would have looked ridiculous doing these antics. Not Ranbir, a complete natural, he makes it all seem cute. Also, the camera just adores this guy. Shoot him from any angle or length, he rocks.

Wake Up Sid is as much about Aisha (Konkona Sen Sharma [ Images ]) as it is about Sid. As the level-headed beauty looking to soar in the field of writing and nursing a crush on her debonair boss (Rahul Khanna in a spiffy cameo), Konkona treads familiar territory. There are occasions when she evokes a strong sense of déjà vu but the actress still finds ways to make her Aisha unique with a mix of patience, warmth, effortless sensuality and wide-eyed romanticism. The unlikely duo share a sublime, comfortable chemistry, which flowers from plausibly awkward to an endearing bonhomie to something truly special in a span of two and a half hours.

Ranbir KapoorThe film, like Sid's life chart, gathers momentum, meaning and melodrama post-interval. But for all its sparkling sweetness and truckloads of eye-candy, the film isn't above flaws.

You cannot fathom how Aisha on the strength of a job interview shifts into a new flat which is quickly transformed into a designer suite. The chanderi-fabric drapes alone must have cost 750 bucks per piece. It's all very visually attractive though. Considering Sid's dreamy imagination and penchant for photography, cinematographer Anil Mehta and production designer Amrita Mahal Nakai whip a tasteful theme of exuberance and youth in every single picture-perfect frame of this man-boy's world.

Digressions apart, notice that while the bond between the (an understated Anupam Kher [ Images ]) father-son is unexaggerated and genuine (one of the most powerful scenes involve a confrontation between the two -- the tension and frustration is almost palpable bolstered with the use of a hand held camera), the moments between Sid and his mom (Supriya Pathak's otherwise effective maternal instincts wasted in spewing silly lines) veer into forced sentimentality. Say what's the logic behind the ideology of connecting to one's brood by jabbering in broken English despite the rude response?

Nevertheless for a first attempt, (barring the end credits video featuring Ranbir rework Zac Efron's High School Musical moves) which is a considerable departure from producer Karan Johar's [ Images ] school of screenplay or style, Ayan Mukherji exudes promise and confidence, skillfully extracting impressive performances from his cast ranging of seasoned veterans as well as rank newcomers.

Wake Up Sid has its heart in place, but it still doesn't have much of a plot or novelty to rely upon. That's why the dialogues could have done with a little more quirk and nifty humour. Having said that, a superlative Ranbir makes it too darn hard to notice.

Rediff Rating:

Sukanya Verma

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By Taran Adarsh

Recall those years when partying hard was the only agenda on your list. Recall those years when staying awake at nights, chatting away with friends became a habit. Recall those years when bunking college and sneaking into movie halls was more exciting than books. Recall those years when you were completely clueless and aimless about the vocation you wanted to pursue once you graduated… That indecisive phase when you were hesitant to take that first big step in life can never be erased from your memory.

WAKE UP SID, directed by debutante Ayan Mukerji, is like revisiting those years that lay at some remote corner of your mind, after you moved on in life.

Actually, WAKE UP SID is a slice of life film. It’s not merely real in concept, but has also been told most realistically, so much so that you can’t help but draw parallels with your life or with someone you know. But what really makes WAKE UP SID most believable is Ranbir Kapoor, who’s mastered the craft at such a young age.

Verdict? WAKE UP SID mirrors those years with flourish. This one’s a simple story that strikes a chord instantly. Strongly recommended!

WAKE UP SID tells the story of Siddharth aka Sid [Ranbir Kapoor], a lazy, unmotivated slacker from Mumbai whose life undergoes a series of changes after taking his final year college exams. Sid’s world is breezy, carefree and without any true responsibilities.

Sid thrives around his two best friends, Rishi [Namit Das] and Laxmi [Shikha Talsania], very rarely communicates with his mother Sarita [Supriya Pathak] and takes his father Ram Mehra [Anupam Kher] and all his hard-earned wealth for granted. Despite all these traits, Sid is an honest boy; sweet, funny and above all, a good friend.

Aisha Bannerjee [Konkona Sen Sharma], an aspiring writer from Kolkata, learns this soon enough when her path crosses with Sid’s on her first day in Mumbai. Ambitious, well-read and driven, Aisha has come to Mumbai to realize her dreams as a writer. Despite their contrasting personalities, Sid becomes Aisha’s first friend in the city.

As Aisha sets up her life in Mumbai, with the help of Sid and his gang, Sid allows for time to fly by over long drives, parties that stretch well into dawn, and endless hours doing absolutely nothing. But a series of circumstances and events compel him to take stock of his life and take a hard look at himself.

Let’s not compare WAKE UP SID with anything you’ve watched before. Not DIL CHAHTA HAI. Not LAKSHYA either. Debutante director Ayan Mukerji narrates a story that you can relate to instantly and treats it with utmost care. A few moments linger in your memory and evoke bitter-sweet memories.

The first hour, right till the intermission, sweeps you off your feet. You get drawn into Sid’s world instantaneously; you react to everything he does. But the post-interval portions slackens, courtesy the writing. The Rahul Khanna track, for instance, looks half-baked. Also, the story stagnates after a point and hence, the pacing gets very slow. It’s only towards the finale that things perk up. Ideally, the film could’ve done with some trimming in this hour.

Ayan Mukerji packs in a solid punch in most parts of the film. The emotional moments especially gets you all moist-eyed. The humour too is well integrated in the sequences. Even the confrontation between the father and son is superb. Prior to that Konkona’s birthday sequence is amongst the finest sequences of the film. Music [Shankar-Ehsaan-Loy] is melodious. Anil Mehta’s cinematography is top notch. Niranjan Iyengar’s dialogues are just right.

There’s no denying that Ranbir Kapoor is a supremely talented actor, but in WAKE UP SID, he proves that he’s amongst the best in the business today. No one could’ve portrayed Sid as effectively as Ranbir has enacted, that’s for sure. This is an award-worthy performance.

Konkona is natural to the core and the best part is, she’s so effortless. Here’s another winning performance from this incredible performer. Anupam Kher is wonderful. Ditto for Supriya Pathak. Both shine in their respective parts. Namit Das and Shikha Talsania are perfect. Rahul Khanna doesn’t get any scope.

On the whole, WAKE UP SID is a well-made film that should strike a chord with the youth mainly. A metro-centric film, the film should attract its target audience and should also prove to be the first choice of the elite/urban audience this Friday. Its distributors [UTV] have very rightly released the film at plexes of metros and mini-metros [instead of flooding the market with physical and digital prints], which in turn should only make this small film talked-about in days to come. Thumbs Up!

Ratings: (4/5)




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